"Elevated Risk of Alzheimer's Disease Among Workers With Likely Electromagnetic Field Exposure"
E. Sobel, PhD; M. Dunn, MS; Z. Davanipour, DVM, PhD; Z.Qian, MS;
H. C. Chui, MD
NEUROLOGY, 47, 1477-1481, December 1996.
We conducted a case-control study of the possible association of occupations with likely exposure to electromagnetic fields and Alzheimer’s Disease(AD) with patients from the Alzheimer’s Disease Treatment and Diagnostic Center, Rancho Los Amigos Medical Center, Downey, CA. Patients with definite or probable AD were the case subjects(86 male, 240 female). Patients with cognitive impairment/dementia other than vascular dementia were control subjects(76 male, 76 female). The study was limited to patients who were at least age 65 at the time of their first examination at Rancho Los Amigos. The odds ratio for both sexes combined was adjusted for sex, education and age at onset. The adjusted odds ratio for both sexes was 3.93(p=0.006, 95%CI=(1.5 to 10.6). For males the adjusted odds ratio was 4.90(p=0.01), 95%CI=(1.3 to 7.9). and for females the adjusted odds ratio was 3.40(p=0.10), 95%CI=(0.8 to 16.0).
THESE RESULTS ARE CONSISTENT WITH PREVIOUS FINDINGS REGARDING THE HYPOTHESIS THAT ELECTROMAGNETIC FIELD EXPOSURE IS ETIOLOGICALLY ASSOCIATED WITH THE OCCURRENCE OF ALZHEIMER'S DISEASE.
"Electromagnetic Field Exposure May Cause Increased Production of Amyloid Beta and Eventually Lead to Alzheimer's Disease"
E. Sobel, PhD and Z. Davanipour, DVM, PhD
NEUROLOGY, 47, 1594-1600, December 1996.
Epidemiologic Findings: Workers with primary occupations likely to have resulted in medium-to-high ELF EMF exposure are at increased risk of Alzheimer's Disease.
Dressmaker, seamstress, tailor, cloth cutter, sewing factory worker
Carpenter, cabinet maker
Machinist, machine operator, machine mechanic, machine shop worker
Keypunch operator, typist, legal typist, clerk typist
Electrician, electrician apprentice, electrical technician, electrical fitter, electrical assembler, electronics assembler, assembler
Tool and dye maker, sheet metal worker, welder
Telephone line/connector worker
EMF exposures result in the release of intracellular calcium ion concentration and increased production of soluble amyloid beta protein(sAb) secreted into the bloodstream.
sAb crosses the blood-brain-barrier in sufficient quantities to eventually cause Alzheimer's Disease.